ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale† BY MARK HALLING-BROWN1,

BY MARK HALLING-BROWN1, FRANCESCO PAPPALARDO2, NICOLAS RAPIN3, PING ZHANG4, DAVIDE ALEMANI5, ANDREW EMERSON6, FILIPPO CASTIGLIONE7, PATRICE DUROUX8, MARZIO PENNISI2, OLIVO MIOTTO9, DANIEL CHURCHILL10, ELDA ROSSI6, DAVID S. MOSS1, CLARE E. SANSOM1, MASSIMO BERNASCHI7, MARIE-PAULE LEFRANC8, SØREN BRUNAK3, OLE LUND3, SANTO MOTTA2, PIER-LUIGI LOLLINI11, ANNALISA MURGO11, ARIANNA PALLADINI11, KAYE E. BASFORD5, VLADIMIR BRUSIC5,12 AND ADRIAN J. SHEPHERD1,∗ 1Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK 2Department of Mathematics and Computer Science, University of Catania, Catania, Italy 3Centre for Biological Sequence Analysis, Danish Technical University, Lyngby, Denmark 4Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, Australia 5School of Land, Crop and Food Sciences, University of Queensland, Brisbane, Australia 6High Performance Systems Division, CINECA, Casalecchio di Reno, Italy 7Institute for Applied Computing, Italian National Research Council (CNR), Rome, Italy 8Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine, CNRS, Montpellier, France 9Institute of Systems Science, National University of Singapore, Singapore 10Division of Information and Technology Studies, University of Hong Kong, Pokfulam, Hong Kong 11Section of Cancer Research, University of Bologna, Italy 12Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston MA, USA